If you have multiple doors or all doors failing to lock unlock with the key fob and the interior door locks it is most likely a larger electrical issue.
Scion door lock issues.
The door actuator going bad is a pretty common maintenance item with cars.
All doors multiple doors fail to lock unlock.
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However if your windows work it may not be the fuse.
It is just a wear and tear item.
It is time to bring it in for repair.
The 2006 scion xb has 7 nhtsa complaints for the latches locks linkages at 67 215 miles average.
All doors multiple doors fail to lock unlock.
For the fuse there is a door window fuse in the fuse box.